Sermorelin Peptide and Growth Hormone Research

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Sermorelin peptide is a synthetically developed peptide that research teams isolated and synthesized from naturally occurring proteins with the hope to extend physiological development and avoid a decline in growth hormone (GH) production.

What Is Sermorelin?

The pituitary gland synthesizes and secures growth hormone (GH). The hypothalamus, positioned slightly above the pituitary gland, produces a growth hormone-releasing hormone (GHRH), promoting the pituitary gland's growth hormone (GH) creation.

An acetate salt of the synthetic peptide known as Sermorelin [i], this compound has 29 amino acids. Research suggests this synthetic peptide, GRF 1-29 NH2, may be designed to potentially simulate the activity of the naturally occurring growth hormone-releasing hormone (GHRH), which comprises 44 amino acid residues.

How Does Sermorelin Act?

The growth hormone-releasing hormone receptors are in the anterior pituitary gland, often known as GHRHr. Researchers speculate that through its interaction with these receptors, Sermorelin may stimulate an increase in the growth hormone (GH) produced and secreted by somatotroph cells [ii].

Scientists hypothesize that an increasing serum concentration of growth hormone (GH) may increase another endogenous hormone named somatostatin, also known as growth hormone inhibiting hormone (GHIH) [iii]. This may occur due to feedback mechanisms responsible for maintaining the levels of hormones.

The growth hormone inhibiting hormone (GHIH) kicks off a negative feedback process to prevent the somatotroph cells from secreting any more growth hormone (GH), which is necessary to prevent an imbalance in the levels of other hormones. Therefore, studies suggest Sermorelin may possibly ensure that the hypothalamus, pituitary, and somatostatin remain in a state of homeostatic coordination.

Findings imply that in addition to this potential, Sermorelin may help enhance the circadian rhythm associated with sleep by tamping the production of stress hormones. The secretion of growth hormone (GH) is further increased.

Sermorelin Peptide Potential

Research suggests Sermorelin may restore and maintain growth hormone (GH) production to optimal levels, which may induce a number of physiological impacts.

Findings imply Sermorelin may be responsible for muscle bulking possibly because it may stimulate the muscle cells to multiply faster, ultimately resulting in increased muscular mass. 

Researchers speculate Sermorelin may promote the rapid repair of damaged tissue. This may occur as a result of the proliferation activity of growth cells that may surround the wound sites. 

Studies also suggest Sermorelin may reduce fat cell storage and impact sleep cycles. The potential of Sermorelin to preserve sleep-related circadian rhythms may contribute to improved sleep quality. 

Sermorelin vs. Ipamorelin

Studies suggest a substantial gap exists in the two peptides' modes of action [iv], even though they appear to perform comparable functions regarding their ultimate purpose. Ipamorelin may act in various ways to stimulate the pituitary gland, which may increase growth hormone production (GH).

Even though they use distinct processes, the proposed synergistic action of the two peptides has led to some astonishing research data. The alleged impacts induced through the peptide’s influence ranged from increased GH levels to arousal and reproductive health, as seen in some animal models.

Sermorelin vs. Modified GRF 1-29

In terms of how they are hypothesized to function, these two peptides are not that different. However, there are discernible structural variations between the two. Four particular amino acids have been changed in the modified version of GRF 1-29, mostly for logistics and to improve growth hormone release (GH).

Sermorelin vs. CJC-1295

Because CJC-1295 is likewise a growth hormone secretagogues (GHS), it may also perform a relatively comparable role to other GHSs [v]. However, the half-lives of Sermorelin and CJC-1295 are very different. Because it has a longer half-life than Sermorelin, CJC-1295 may maintain its presence in serum longer and exert its effects longer than the latter.

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[i] Prakash A, Goa KL. Sermorelin: a review of its use in the diagnosis and treatment of children with idiopathic growth hormone deficiency. BioDrugs. 1999 Aug;12(2):139-57. doi: 10.2165/00063030-199912020-00007. PMID: 18031173.

[ii] Brian L. Furman, in xPharm: The Comprehensive Pharmacology Reference, 2007

[iii] Olarescu NC, Gunawardane K, Hansen TK, et al. Normal Physiology of Growth Hormone in Adults. [Updated 2019 Oct 16]. In: Feingold KR, Anawalt B, Blackman MR, et al., editors. Endotext [Internet]. South Dartmouth (MA):, Inc.; 2000-. Available from:

[iv] Vittone J, Blackman MR, Busby-Whitehead J, Tsiao C, Stewart KJ, Tobin J, Stevens T, Bellantoni MF, Rogers MA, Baumann G, Roth J, Harman SM, Spencer RG. Effects of single nightly injections of growth hormone-releasing hormone (GHRH 1-29) in healthy elderly men. Metabolism. 1997 Jan;46(1):89-96. doi: 10.1016/s0026-0495(97)90174-8. PMID: 9005976.

[v] Jetté L, Léger R, Thibaudeau K, Benquet C, Robitaille M, Pellerin I, Paradis V, van Wyk P, Pham K, Bridon DP. Human growth hormone-releasing factor (hGRF)1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats: identification of CJC-1295 as a long-lasting GRF analog. Endocrinology. 2005 Jul;146(7):3052-8. doi: 10.1210/en.2004-1286. Epub 2005 Apr 7. PMID: 15817669.

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I'm Alice and I live with a dizzying assortment of invisible disabilities, including ADHD and fibromyalgia. I write to raise awareness and end the stigma surrounding mental and chronic illnesses of all kinds. 

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